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To detect GLP-1R activity in the ex-vivo assay over a sufficient period of time for accurate half-life determination, the dose of the glycosylated variant in the PK stability experiment had to be increased to 40 mg/kg compared to 5 mg/kg for the non-glycosylated fusion

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Whether knocking out the GPX4 gene or inhibiting its activity, it can eventually lead to a redox homeostasis imbalance that can have a fatal effect on normal or tumor cells

Neurochem Res (2012) 37(8):16819