when do you start to feel the effects of semaglutide How Long Does Take Suppress Appetite? What to Expect During the

That's a gap of 50-100x, not a minor difference

In the SURMOUNT-1 trial, tirzepatide demonstrated 15-22% weight loss over 72 weeks

Kim et al., 2015

From meta-analyses including 3,092 patients from eight RCTs comparing pioglitazone in combination with any insulin-containing regimen compared to the same insulin regimen alone, pioglitazone confers a small advantage in terms of HbA1c in T2DM patients with previous inadequate glucose control but at the cost of increased hypoglycemia and weight gain [24]

There is no single universal dose, and prescribing follows MHRA-approved product characteristics alongside NICE guidance