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A landmark trial published in 2023 found that semaglutide reduced the risk of major cardiovascular events heart attack, stroke, and cardiovascular death by 20% in people with obesity and established cardiovascular disease

However, instead of being taken once weekly, the Wegovy pill is taken orally once a day

The results provide much-needed reassurance regarding the psychiatric safety of these drugs and contribute to recent studies that also found no link to suicidality, Azoulay said

However, in contrast to our results, their study found that semaglutide was associated with a higher risk of serious adverse events [39]