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The third class has the highest inhibitory function toward DPP4, because both sita- and teneligliptin interact with the S2-extensive subsite of the DPP4 active center, and an increasing number of interactions seems to increase the potency of the gliptin (10)

At the endpoint, those taking CagriSema lost an average of 23% of their body weight (which started at 114.2 kg on average)