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The primary efficacy endpoint of the larger trial did not reach statistical significance, warranting confirmation in future studies

These microbial communities comprise a significant population of butyrate-producers, including various butyrogenic species of Eubacterium , Faecalibacterium , and Roseburia (Manson et al., 2008

Furthermore, there is an urgent need for reliable biomarkers and imaging techniques that can detect OA at an early stage so that interventions can be carried out before irreversible joint damage occurs

10.1128/aem.63.9.3732-3735.1997 Appl

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