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On blood sugar, participants taking 36 mg of orforglipron saw A1C fall by close to 2 percentage points, compared with roughly 1.5 points for those on 14 mg of oral semaglutide, as Scientific American reported

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Its prevalence has risen dramatically since 1980, when it was a perplexing and sporadically-observed disease as first reported by Ludwig and colleagues (1), to a current estimated 25% global prevalence.(2) NAFLD represents the leading cause of chronic liver disease and is the second leading indication for liver transplantation in the United States.(3) Its rise parallels the obesity epidemic and is attributed to the concomitant rise in the prevalence of type 2 diabetes and metabolic syndrome

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Keri Gans, RD, is the author of The Small Change Diet