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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion
These may include: Blood sugar abnormalities High blood pressure Headaches and nausea Hormonal imbalances Muscle damage Long-term misuse may increase the risk of blood clots, bone loss, and certain cancers
This is a genuine, published mechanistic pathway, but it has only been demonstrated in cell and mouse models, not in humans
Cellular senescence: "Zombie cells" that secrete inflammatory factors, promoting further aging
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