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J Biol Chem 282:3045265, PMID: 17724027 Ji L, Shen K, Jiang P, Morahan G, Wang Z (2011) Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells

These effects contribute to the healing and regeneration of damaged tissues, which can lead to pain relief and improved function

this difference in receptor binding may lead to a differential recruitment of downstream neuronal pathway in rodent models and in vivo body weight lowering effect

This means it has antimetastatic effect as was showed in the research of spontaneous tumorigenesis in female mice mostly with tumors of the reproductive organs as mammary glands and ovaries

This is made even more problematic, given the number of factors that can deplete glutathione levels