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Required for energy metabolism and antioxidant recycling

JAMA (2013) 309:5707.10.1001/jama.2012.155925 105 JamesSJCutlerPMelnykSJerniganSJanakLGaylorDWet alMetabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

T cells from SLE patients (227, 228) and lupus-prone mice (229) have abnormally high expression of CaMK4, which activates the AKT-mTOR pathway to promote Th17 cell development and IL-17 release.Th17 cell differentiation can be considerably decreased by blocking the CaMK4-AKT-mTOR pathway (230)

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced