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This result makes the peptide potentially safer for individuals with diabetes or prediabetes

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

The chemical and biochemical basis for this difference in toxicity remains elusive

The normal functions of antioxidant GPX4 and cystine transporter System X c are of great importance in controlling ferroptosis

[DOI] [PubMed] [Google Scholar] 46.Leopold J