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In our animal experiment, the combination of metformin and liraglutide induced significant changes in the gut microbiota of PCOS rats

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found that FOXO1 represses the survival of osteosarcoma cells by inhibition of the Wnt/-catenin signaling, showing that the inhibition of Wnt/-catenin signaling by FOXOs is conserved during the development of bone and osseous tumorigenesis