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Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

This is why it is important to monitor your blood pressure regularly if you are taking semaglutide

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However, eligibility is also extended to individuals with a lower BMI of 27 or greater if they have at least one weight-related health condition