Allergen information: Free from shellfish
Additional side effects may include: Mild diarrhea or nausea shortly after injection
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme highly expressed in adipose tissue and liver that consumes SAM (S-adenosylmethionine) to methylate nicotinamide, simultaneously depleting methyl donor pools and reducing NAD+ precursor availability in a manner that promotes adipogenesis and metabolic dysfunction
ACSL4 can catalyze the esterification of PUFAs in phospholipids on cellular membranes and enhance ferroptosis sensitivity to lipid peroxidation (Zhang et al., 2025c)
Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention
