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PT-141's MC1R binding affinity is 50-fold lower than its MC4R affinity, meaning the dose required to produce melanogenesis would far exceed the dose that causes intolerable MC4R-mediated side effects like nausea and blood pressure elevation

Additionally, GHK-Cu: Promotes wound healing and reduces post-acne scarring Modulates matrix metalloproteinases (MMPs), preventing excessive tissue breakdown Supports balanced skin remodelling This makes it particularly effective for: Active acne Acne-prone skin undergoing treatments Post-inflammatory hyperpigmentation and scarring By integrating GHK-Cu into acne protocols, we not only treat breakouts but actively repair and strengthen the skinreducing recurrence and improving long-term skin health

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Graf ER, Zhang X, Jin S-X, Linhoff MW, Craig AM

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