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Mechanistically, the metabolic benefits of Godex depend on enhanced activity of CrAT, which modulates mitochondrial acetyl-CoA metabolism and thereby improves insulin sensitivity and hepatic lipid homeostasis (80), whereas some human studies report only modest reductions in liver enzymes without significant changes in broader metabolic parameters (64)

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We found that semaglutide distinctively modifies pancreatic islet physiology and morphology depending on the diet