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doi: 10.1038/nrgastro.2015.150 11 SampsonTRDebeliusJWThronTJanssenSShastriGGIlhanZEet al

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BPC-157 upregulates VEGFR2 expression in vascular endothelial cells at both mRNA and protein levels without increasing VEGF-A production, suggesting the peptide sensitizes endothelial cells to existing VEGF rather than simply increasing ligand availability

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At low concentrations, curcumin primarily interacts with the polar heads of the outer membrane surface