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Morel F, Rauch C, Petit E et al (2004) Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization

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Specifically, HMGB1 regulates platelet activation, granule secretion, adhesion, and spreading via the TLR4 pathway on platelets

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Together these results suggested that the balancing of oxidative cellular status involves the increase in active GSH efflux to extracellular medium [36]

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Treatments might include injections or high-dose oral supplements to restore B12 levels

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