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Virulent Pseudomonas syringae secretes multiple effectors that cooperate to reprogram the expression of photosynthesis-associated nuclear genes ( PhANGs ) and target the chloroplast to prevent the chloroplastic ROS burst by impairing PSI 6

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The combination of CB-839 and azacytidine (AZA) was found to be synergistic in a single-arm, open-label, phase 1b/2 study conducted in patients diagnosed with advanced myelodysplastic syndromes (MDS)