Patients should seek urgent medical attention if they experience signs of a severe allergic reaction (such as widespread rash, facial or tongue swelling, or breathing difficulties) or extensive skin reactions
Individuals who may warrant closer monitoring include: Those with a personal or family history of depression , anxiety, or other mood disorders People who have previously experienced mood changes on other weight-loss medications or GLP-1-based therapies Individuals with eating disorders or a complex relationship with food , for whom appetite suppression may have psychological implications (see NICE guideline NG69: Eating disorders: recognition and treatment) [10] Those experiencing significant life stressors alongside starting a new treatment People with poorly controlled type 2 diabetes , where fluctuating blood glucose levels both hypoglycaemia and hyperglycaemia can independently affect mood, concentration, and emotional wellbeing It is also worth acknowledging that obesity itself is associated with higher rates of depression and anxiety, and that the psychological experience of rapid body weight change whether positive or negative can be emotionally complex
"Look for words that are spelled wrong, missing punctuation, capital letters in the middle of sentences and sentences that just don't make any sense," Schiller said
The greatest amount of weight loss is often observed after three to six months of continuous therapy, especially when combined with a healthy diet and increased physical activity
5d and e and 143 significantly differentially proteins, including 48 upregulated and 95 downregulated proteins, was identified
