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Furthermore, it provides a critical appraisal of recent human observational data, distinguishing metabolic benefits from intrinsic disease-modifying effects, and outlines the practical clinical friction points and prospective trials necessary to validate these pathways in future treatment paradigms

The inability to definitively establish causality is a constraint shared by all pharmacovigilance studies and observational cohort studies [Reference Ruiz, Cocores, Tosti, Goadsby and Monteith50, Reference Wichelmann, Abdulmujeeb and Ehrenpreis51]

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Dietary high zinc oxide modulates the microbiome of ileum and colon in weaned piglets