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Physical transformation without psychological adaptation is incomplete

142 In addition, ERAD directly restrains hepatic lipogenesis by targeting ATP-citrate lyase (Acly), a key enzyme that channels citrate toward fatty acid synthesis

Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137

3 Biotech (2021) 11(4):179