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The main difference is that Retatrutide is a triple-agonist, targeting GLP-1, GIP, and the Glucagon receptors

IRE1 phosphorylates JNK, which then results in impaired insulin signaling through inhibition of IRS1 and IkB kinase, leading to NF-B activation and inflammatory responses [99]

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For example, a patient with a GLP1R rs6923761 'T' allele may show enhanced GLP-1 receptor sensitivity, potentially supporting a conversation about lower-dose compounded GLP-1 protocols

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