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Nausea, vomiting, and diarrhea were more common in the highest 15mg dose of tirzepatide compared to lower 0.5 mg dosages of semaglutide, suggesting the latter may be a good option to minimize these side effects, although of course, with the trade-off being less weight loss, Wong, who was not involved in the study, told Medical News Today

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These gastrointestinal effects typically occur early in treatment and often diminish over time as the body adjusts to the medication