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Both Zepbound (tirzepatide) and Wegovy (semaglutide) are effective weight-loss medications for adults with obesity or overweight and at least one weight-related health condition

it is a fundamental requirement that dictates patient comfort, medication absorption rates, and overall tissue safety

Extended use of TRZ is associated with the development of gastrointestinal adverse effects such as nausea, dyspepsia, vomiting, abdominal pain, diarrhea or constipation, and hypoglycemia

One mouse study found no increase in mean lifespan, although maximum-lifespan measurements among the longest-surviving animals changed