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Conversely, ferroptosis inhibitors significantly attenuate 6-OHDA-induced neuronal damage ( /GPX4 signaling axis in the prefrontal cortex of AD mice, upregulates ferritin light chain (FTL) and -site amyloid precursor protein cleaving enzyme 1 (BACE1), downregulates 4-hydroxynonenal (4-HNE), inhibits ferroptosis and lipid peroxidation, and ameliorates cognitive deficits (Li et al., 2024a)

In the forced swimming test, PE-22-28 reduced immobility time comparably to the SSRI fluoxetine