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Collectively, boosting intestinal AMPKNAMPT-NAD + biosynthesis could benefit systemic glucose metabolism by maintaining intestinal homeostasis, including GLP-1 synthesis and microbial composition (Figure 3)

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So theres no data on whether the GLP-1 bump lastsor disappears the moment you stop

The liver fat advantage is more pronounced, with retatrutide achieving 82% reduction compared to more modest figures for tirzepatide

Common side effects may include: Nausea Vomiting Diarrhea Constipation Reduced appetite Abdominal discomfort Fatigue Dizziness Possible blood sugar changes Patients should seek medical guidance if side effects become severe, persistent, or difficult to manage