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Conditions such as diabetes mellitus, multiple sclerosis (MS), and systemic lupus erythematosus have been associated with oxidative stress, potentially exacerbating DED (Lu et al., 2018

S2CID 31245042

What to Expect in Month 1 Appetite changes: Noticeable suppression begins week 3-4 for most Mild nausea: 40% experience some nausea, usually mild Injection site reactions: Redness, itching, or mild pain at injection site (14% of patients) Fatigue: Some patients report low energy as body adjusts Bowel changes: Either constipation or looser stools as medication affects gut motility 4 Essential Strategies for Month 1 1

This is the opposite of the intended therapeutic effect

Vitamin K 2 can also be provided by gut bacteria, even though in insufficient amounts [304, 308]