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This includes a vast array of studies such as investigating cellular mechanisms, exploring therapeutic potentials, drug discovery, or understanding complex biological pathways
Autoimmunity could contribute, at least in part, to the hypothalamus-pituitary axis impairment in these individuals, in addition to the genetically determined dysfunction ( Researchers have looked into whether the symptoms of PWS differ based on the underlying genetic cause
Younger patients metabolize medications differently, have different cardiovascular risk profiles, and face unique developmental considerations
Incidence rates of Permanent link to this article: ICARE Newsletter Winter 2018 Advances in New Treatments for Individuals with Lynch Syndrome ICARE Newsletter Winter 2018 Advances in New Treatments for Individuals with Lynch Syndrome A recently published phase II clinical trial investigated the use of a new class of drugs (called PD-1 Inhibitors) in DNA mismatch repair-deficient/ microsatellite instability-high colorectal tumors (which are features seen in the majority of colorectal tumors from individuals with Lynch Syndrome) among patients with metastatic disease.1 Investigators found patients who received two PD-1 Inhibitors Permanent link to this article: ICARE Newsletter Winter 2018 Study Suggests Inherited Cancer Genes Are Important in Pancreatic Cancer ICARE Newsletter Winter 2018 Study Suggests Inherited Cancer Genes Are Important in Pancreatic Cancer In a recent study which included over 800 patients with pancreatic ductal cancer, inherited cancer gene mutations were found in a much higher proportion than expected
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