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Indeed, SIRT1 has been reported to play a key role in tumorigenesis, as an oncogene or tumor suppressor depending on the context specificity ( via deacetylation of lysine groups of histone and non-histone proteins, including known transcription factors (FOXO, MyoD, p53, PGC-1) (Kupis et al., 2016)

doi: 10.1126/scitranslmed.aag2942 108 KlionskyDJAbdel-AzizAKAbdelfatahSAbdellatifMAbdoliAAbelSet al

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