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These findings suggest that the amplification of neuroinflammation following Anesthesia/surgery-triggered central inflammation play a significant role in the pathophysiology of PND

Erastin can interact with VDAC2 protein to trigger mitochondrial malfunction and oxidative substance release, eventually leading to oxidative cell death, i.e., ferroptosis (53) (Figure 1)

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B12 injections deliver the vitamin directly into the bloodstream, ensuring maximum absorption and immediate effects, whereas oral supplements must pass through the digestive system, which can result in lower absorption rates and slower onset of action

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