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FDA Warning: RISK OF THYROID C-CELL TUMORS Other GLP-1 agonists been found to cause a dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures in both genders of rats and mice

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More importantly, the hazard ratio for major adverse cardiovascular events (including cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina) for the pooled tirzepatide groups versus glargine was 0.74 (95% CI 0.511.08), suggesting no increased cardiovascular risk with tirzepatide compared to insulin glargine

By loading anti-inflammatory and tissue-repair molecules onto the acupuncture, these approaches achieved synergistic therapy where the needle delivers the drug upon insertion, establishing a new paradigm for localised, precise drug administration in KOA (35, 36)