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In some embodiments, the otic formulation or composition comprises about 10% by weight of the viscosity modulating agent(s)

If untreated, B12 deficiency can lead to serious neurological and cardiovascular complications

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We evaluated the bioavailability, functional enrichment profiles and drug-protein interactions of these repurposed agents and evidenced their cellular viability and efficacy in glial cell culture by experimental assays and Western blotting