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While CKD increases various uremic toxins, clinical evidence has established that indoxyl sulfate serves as an independent, powerful risk factor for cardiovascular mortality and adverse cardiovascular events (67, 68), and its levels also associate with the severity of coronary atherosclerosis (67, 69)

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A comprehensive review of recent clinical data highlights that while folate deficiency is common among individuals with ASD, maternal folic acid supplementation does not correlate with higher risk of the disorder, indeed folate therapy has been associated with improved neurodevelopmental outcomes (Vasconcelos et al., 2025)

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