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While the specific details of the ECD interface of Cagri-AMY 3 R could not be determined due to the low-resolution maps, these findings are indicative of substantial loss of RAMP3/CTR ECD interface interactions and considerable dynamic motions within the RAMP3 and CTR ECD protomers (Fig

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This process is regulated by local and systemic growth factors, including those of the somatotropic axis, which is the signaling between growth hormone (GH) and insulin-like growth factor-1 (IGF-1)

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