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The analysis is based on results from the STEP 1 trial, published in 2021 in the New England Journal of Medicine , which showed the 2.4 mg dosage of semaglutide approved by the FDA for the treatment of obesity reduced body weight by an average of 14.9% along with reductions in several cardiovascular risk factors such as blood pressure and lipids
Gender-specific data were available in some studies, reporting 268 males and 288 females
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Altering this pathway through NNMT inhibition has been shown in preclinical settings to increase caloric expenditure while reducing storage
The LEADER trial demonstrated a significant reduction in the rate of cardiovascular death, nonfatal MI, or nonfatal stroke in patients with type II diabetes treated with liraglutide
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