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Transmission electron microscopy (TEM) imaging of OsO 4 -postfixed HEK293T cells showed that surface LaccID provides excellent contrast at the plasma membrane, with minimal staining of intracellular membranes on the ER, mitochondria and nucleus (Fig

Iron overload was also associated with metabolic remodeling, as evidenced by increased phosphorylation ratios of Akt Thr308 and AMPK (Figure 8H)