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AOD-9604 is a modified version of this fragment, designed to enhance stability and activity in fat metabolism

but these negative effects were not seen with light- and moderate-intensity exercise or when exercise occurred two to four hours before bedtime

This can be justified by studies showing high metabolic activity in the cerebellar nuclei in Lurcher mice, which could lead to high oxygen free radical and neurons death due to toxicity in older Lurcher mice [137, 154]

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The combination treatment was more effective and faster acting than standalone fumaric acid esters