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While large peptides like SE do not readily cross the blood-brain barrier, they are known to access the brain through circumventricular organs (CVOs)specialized regions with fenestrated capillaries ( in vitro data provides direct evidence for this central action, demonstrating that SE can modulate ABCA2 and SGPP1 expression in neuronal cells independent of any peripheral factors

Abstract Introduction: Irritable bowel syndrome (IBS) is a severe gastrointestinal condition with symptoms like pain, bloating, diarrhea, and constipation

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