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The D-alanine substitution at position 2 is specifically directed at blocking the primary DPP-4 cleavage site, while the remaining substitutions prevent additional enzymatic attack at susceptible positions and reduce oxidative degradation during storage and in vivo

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MT-2 Molecular Identity: Quick Reference MT-2 vs MT-1: A Researchers Comparison The two compounds most frequently compared in the Melanotan research peptide category are MT-2 and MT-1 (Afamelanotide)

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