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Another Phase Ib/II trial exploring the safety and efficacy of capmatinib treatment with cetuximab, an anti-EGFR antibody, in HNSCC and metastatic colorectal cancers positive for c-MET has recently been suspended for unknown reasons (NCT02205398)

Be sure to tell the prescriber about all medications and supplements that are being taken so they can monitor for drug interactions

Not to ask permission sponsors who ask permission in pre-Phase 3 meetings get conservative answers but to surface the divisions current thinking on endpoint selection, population definition, and the mechanistic evidence threshold for a supplemental NDA

The last decade has been characterized by a dramatic increase in the number of children diagnosed with ASD

486 Intellectual disability Intellectual disability (ID) is a heterogeneous genetic disorder in children with an incidence of 13%, representing a substantial public health burden