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Furthermore, TMAO-induced activation of the NLRP3 inflammasome, a proinflammatory protein complex, results in increased production of the proinflammatory cytokine IL-1 both in vitro and in vivo , which contributes to endothelial injury ( + -dependent protein deacetylase sirtuin3 (Sirt3) and subsequent inhibition of manganese superoxide dismutase 2 (SOD2) activation (Rogacev et al., 2012

[28],[29],[30],[31],[32] Pseudonetwork can be observed in dermatoscopic examination of certain benign pigmented facial lesions such as AK, ephelide, and junctional nevus

Multiple groups were compared using ANOVA

Vital signs and anthropometric measurements at presentation are summarized in Table 2

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