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However, when 4-OHT treatment is initiated at E11.5, nearly all vessels, including lymphatic vessels, are GFP + (Supplementary Fig

Data are expressed as mean + SEM

Additionally, a few medications are being used to reduce symptoms pre-surgically, such as gonadotropin-releasing hormone agonists, SERMs (selective estrogen receptor modulators) and aromatase inhibitors

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The arcuate nucleus contains two distinct populations of neurons: one that produces neuropeptide Y (NPY) and agouti-related peptide (AgRP ) and another that produces pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART)