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These mechanisms collectively trigger and sustain inflammation, atherosclerosis, and organ-specific complications such as retinopathy, nephropathy, neuropathy, metabolic-dysfunction associated steatotic liver disease (MASLD), cardiopathy, and brain disease [5]

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You may have health issues that interfere with your bodys ability to absorb the nutrient, you might not be getting enough in your diet, or you could be taking drugs that lower the levels of B12 in your body