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Cancer 100 , 690697 (2002)

Wegovy is a GLP-1 receptor agonist administered by subcutaneous injection, bypassing the gastrointestinal tract and reducing likelihood of direct interactions with oral probiotics

Against those benchmarks, oral agents currently sit at a level of efficacy that is meaningful but measurably lower

Resmetirom provides significant low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) reduction along with early hepatic antifibrotic effects, whereas semaglutide leads to substantial weight loss and wide-ranging cardiometabolic improvements

The same gastrointestinal side effects, central adaptations, and pleiotropic actions that once discouraged development are now recognized as manageable features of peptide pharmacology when appropriately contextualized