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Statements Author contributions ZH: Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing original draft, Writing review & editing

Here, SAMe inhibited the effects of B vitamin deficiency to induce PSEN1 and BACE1 expression and tau phosphorylation in TgCRND8 and wild-type mice

No changes in the BMD were observed after 3 months of the intervention

Higher levels are linked to better insulin sensitivity, lower inflammation, and a stronger gut barrier

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