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So the third mechanism of action is around slowing stomach emptying and slowing what we call gastric emptying that process leaves food in the stomach for longer therefore there is less necessity to go looking for food and finally, the action is around the effect on the pancreas where GLP-1s both increase the amount of insulin that is produced as well as increase the amount that is released

Typical reta dosage in rodent metabolic studies ranges from 0.1-3.0 mg/kg subcutaneously, administered daily or every other day due to shorter rodent half-life compared to humans

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You still want to have a slow, steady weight loss with slow dose titration

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