highest semaglutide dose cardiovascular outcomes align more closely with attained than achieved weight loss Higher-Dose Semaglutide Injection Proves Mettle

The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis

doi:10.1038/s41591-023-02669-x Nunn E, Jaiswal N, Gavin M, et al

Second, the 9 mg arm discontinued at a higher rate than the 12 mg arm, which is not a dose-response pattern

TEXT ON-SCREEN: CHECK: Check the flow

Cross-trial comparisons have real limits