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In contrast, the pull model postulates that consumption of food with a high glycemic load stimulates insulin, which alters fuel partitioning, inhibiting mitochondrial respiration and fatty acid utilization (78, 79) and promoting fat deposition into adipose tissue, stimulating hunger and further consumption

We performed a hierarchical cluster analysis of differentially expressed genes (DEGs) to evaluate gene expression patterns between groups and samples

These gastrointestinal problems are often the most reported side effects

Metformin is a diabetes medication sometimes used off-label for weight loss, especially in patients with insulin resistance or prediabetes

Long answer: Like any supplement, misuse, excessive dosing, or poor product quality can create risk