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Open Access Emerg Med

Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

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Indeed, we observed up-regulation of several solute carrier (SLC) membrane transporters (Fig S1D), implying a potentially crucial role of membrane transporters in adapting to metal-induced toxicity