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Patients with a history of diabetic retinopathy should be monitored by an eye doctor

Unlike MC4R-targeted agonists such as setmelanotide, whose efficacy is intrinsically limited by the functional status of the impaired receptor, GLP-1 RAs operate via pathways largely independent of the leptin-melanocortin circuitry

Lee: GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain, particularly the hypothalamus, which regulates many core functions, including hormones, temperature, and appetite

Vitamin D is a fat-soluble vitamin, meaning that it does not dissolve in water and is absorbed best in your bloodstream when paired with high fat foods

Understanding these motivations helps clinicians provide individualized guidance for safe discontinuation when appropriate, while also addressing modifiable barriers that might allow continued therapy when clinically beneficial